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(-)-Aspartic acid

Name: (-)-Aspartic acid
Brand: TargetMol
SKU: T4885
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4885Cas No. 1783-96-6

Alias D-Aspartic acid, D-(-)-Aspartic acid, asparagic acid, Asp, Aminosuccinic acid

(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor.

(-)-Aspartic acid

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Purity: 99.89%

Catalog No. T4885Alias D-Aspartic acid, D-(-)-Aspartic acid, asparagic acid, Asp, Aminosuccinic acidCas No. 1783-96-6

(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock

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Purity:99.89%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

(-)-Aspartic acid AI Summary

(-)-Aspartic acid demonstrates various bioactivities and interactions at multiple receptors and transporters. At a concentration of 5 μM, it shows a 58.0% inhibition of L-Glutamate uptake when using [3H]-L-glutamate radioligand. It acts as an agonist at mGlu1-alpha, mGlu2, and mGlu6 receptors in CHO cells, with an EC50 value greater than 1,000,000 nM. Additionally, (-)-Aspartic acid inhibits the displacement of [3H]CPP from N-methyl-D-aspartate (NMDA) glutamate receptors in rat brain membranes with an IC50 value of 10,000 nM, indicating a role in NMDA receptor modulation. It also binds with high affinity to the Pyrococcus horikoshii sodium-coupled aspartate transporter, with Kd values of 10 nM and 9 nM in different assays, suggesting its potential as a ligand for transporter modulation. The compound is reported to exhibit agonistic activity at the Thyroid Stimulating Hormone Receptor, inhibit Bacillus subtilis Sfp phosphopantetheinyl transferase, and act as an activator of intracellular cAMP concentrations. It also shows inhibitory action against the malarial parasite plastid, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and Human Apurinic/apyrimidinic Endonuclease 1 (APE1). Moreover, (-)-Aspartic acid inhibits the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) with an EC50 value of 398,000 nM, based on phenotypic assays detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells. This diverse range of bioactivities implies potential therapeutic roles in various biochemical pathways and disease states..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor.
Synonyms	D-Aspartic acid, D-(-)-Aspartic acid, asparagic acid, Asp, Aminosuccinic acid

Chemical Properties

Molecular Weight	133.1
Formula	C₄H₇NO₄
Cas No.	1783-96-6
Smiles	[C@@H](CC(O)=O)(C(O)=O)N
Relative Density.	1.66 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 3.28 mg/mL (24.64 mM), Sonication is recommended.

1eq. NaOH: 100 mM, Sonication is recommended.

Ethanol: Insoluble

Solution Preparation Table

H2O/1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	7.5131 mL	37.5657 mL	75.1315 mL	375.6574 mL
5 mM	1.5026 mL	7.5131 mL	15.0263 mL	75.1315 mL
10 mM	0.7513 mL	3.7566 mL	7.5131 mL	37.5657 mL
20 mM	0.3757 mL	1.8783 mL	3.7566 mL	18.7829 mL

1eq. NaOH

	1mg	5mg	10mg	50mg
50 mM	0.1503 mL	0.7513 mL	1.5026 mL	7.5131 mL
100 mM	0.0751 mL	0.3757 mL	0.7513 mL	3.7566 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc